Using physiologically-active cell culture models that can be made high-throughput, compound libraries will be tested in their ability to improve metabolic disease phenotypes. Further, identification of bacterial machinery responsible for making metabolites that disrupt intestinal homeostasis will allow generation of precise chemical tools that can manipulate the gut microbiome to elicit responses at organismal levels. Refs: Science Advances 2022, Nature Chemical Biology 2021, Nature Chemical Biology 2020