A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgeryChen Y, Chaudhari SN, Harris DA, Roberts CF, Moscalu A, Mathur V, Zhao L, Tavakkoli A, Devlin AS, Sheu EG.
Cell Host & Microbe 2024 32, 1315–1330
Recent advancements in the structural exploration of TGR5 agonists for diabetes treatmentBhimanwar RS, Mittal A, Chaudhari SN, Sharma V.
RSC Med. Chem 2024,15(9):3026-3037 doi: 10.1039/d4md00473f
Host-microbiome orchestration of the sulfated metabolome
D’Agostino GD, Chaudhari SN, Devlin AS.
Nature Chemical Biology 2024, doi: 10.1038/s41589-023-01526-9
Highlights from the 24th workshop on vitamin D in Austin, September 2022
Meyer MB, Bernal-Mizrachi C, Bickle DD, Biyani M, Campbell MJ, Chaudhari SN, et. al.
J Steroid Biochem Mol Biol 2023 (10), 228:106247
Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury
Li DK, Chaudhari SN, Lee Y, Sojoodi M, Adhikari AA, Zukerberg L, Shroff S, Barrett SC, Tanabe K, Chung RT, Devlin AS.
Science Advances 2022, 8 (34).
Research spotlight: Harvard Medical School Instagram
Chains of evidence from correlations to causal molecules in microbiome-linked diseases
Chaudhari SN, McCurry MD, Devlin AS.
Nature Chemical Biology 2021, 17 (10), 1046–1056.
Research spotlight: Nature Chemical Biology cover
A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases
Adhikari AA, Ramachandran D, Chaudhari SN, Powell CE, McCurry MD, Banks AS, Devlin AS.
ACS Chemical Biology 2021, 16 (8), 1401–1412.
Intestinal co-culture system to study TGR5 agonism and gut restriction
Chaudhari SN, Devlin AS.
Bio-protocol 2021, 11 (6), e3948.
A microbial metabolite remodels the gut-liver axis following bariatric surgery
Chaudhari SN, Luo JN, Harris DA, Aliakbarian H, Yao L, Paik D, Subramaniam R, Adhikari AA, Vernon AH, Kilic A, Weiss ST, Huh JR, Sheu EG, Devlin AS.
Cell Host & Microbe 2021, 29 (3), 408–424.e7.
Research Spotlight: Cell Host & Microbe preview
Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects
Chaudhari SN, Harris DA, Aliakbarian H, Luo JN, Henke MT, Subramaniam R, Vernon AH, Tavakkoli A, Sheu EG, Devlin AS.
Nature Chemical Biology 2021, 17 (1), 20–29.
Research spotlight: c&en drug discovery, Nature Chemical Biology News & Views, Harvard Medical School News and Research, Translational Chemical Biology conference press highlight
Development of a covalent inhibitor of gut bacterial bile salt hydrolases
Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD, Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin AS.
Nature Chemical Biology 2020, 16 (3), 318–326.
Research spotlight: Nature Chemical Biology cover
The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity
Chaudhari SN & Kipreos ET.
Bioessays 2018, e1800005
Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
Chaudhari SN & Kipreos ET.
Nature Communications 2017, 8, 182
Dafachronic acid inhibits C. elegans germ cell proliferation in a DAF-12-dependent manner
Mukherjee M, Chaudhari SN, Balachandran RS, Vagasi AS & Kipreos ET.
Developmental Biology 2017, 432, 215-221,
Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation
Chaudhari SN, Mukherjee M, Vagasi AS, Bi G, Rahman MM, Nguyen CQ, Paul L, Selhub J, Kipreos ET.
Developmental Cell 2016, 38, 33-46
Research spotlight: Developmental Cell preview
Primary Culture System for Germ Cells from Caenorhabditis elegans Tumorous Germline Mutants
Vagasi AS, Bi G, Rahman MM, Chaudhari SN, Kipreos ET.
Bio Protoc 2017, 7 (15), e2424
Enhanced resolution through thick tissue with structured illumination and adaptive optics
Thomas B, Wolstenholme A, Chaudhari SN, Kipreos ET, Kner P.
J. Biomed. Opt. 2015, 0001;20(2):026006.
Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells
Danner R, Chaudhari SN, Rosenberger J, Richie TL, Brumeanu T, Casares S.
PLoS ONE 2011, 6: e19826
Patents
Methods for inducing bile acid sulfotransferase sult2a for treating metabolic disorders WO-2021226447-A1 link
Synthetic derivatives of cholic acid-7-sulfate and uses thereof
WO/2020/117945 link
Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetesWO2020041673A1 link