Publications

Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia

Chaudhari SN, Chen Y, Ferraz-Bannitz R, Cummings C, Sheehan A, Querol PC, Ozturk B, Wang H, D’Agostino G, Ye F, Sheu EG, Devlin AS & Patti ME.

Nature Metabolism 2025 volume 7, pages792–807

BAAT away liver cancer: conjugated bile acids impair T cell function in hepatocellular carcinoma immunotherapy

Detwiler Z, Chaudhari SN

Immunometabolism 2025 7(2):p e00062

A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery

Chen Y, Chaudhari SN, Harris DA, Roberts CF, Moscalu A, Mathur V, Zhao L, Tavakkoli A, Devlin AS, Sheu EG.

Cell Host & Microbe 2024 32, 1315–1330

A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery

Chen Y, Chaudhari SN, Harris DA, Roberts CF, Moscalu A, Mathur V, Zhao L, Tavakkoli A, Devlin AS, Sheu EG.
Cell Host & Microbe 2024 32, 1315–1330

Recent advancements in the structural exploration of TGR5 agonists for diabetes treatment

Bhimanwar RS, Mittal A, Chaudhari SN, Sharma V.
RSC Med. Chem 2024,15(9):3026-3037 doi: 10.1039/d4md00473f

Recent advancements in the structural exploration of TGR5 agonists for diabetes treatment

Bhimanwar RS, Mittal A, Chaudhari SN, Sharma V.
RSC Med. Chem 2024,15(9):3026-3037 doi: 10.1039/d4md00473f

Host-microbiome orchestration of the sulfated metabolome

D’Agostino GD, Chaudhari SN, Devlin AS.
Nature Chemical Biology 2024, doi: 10.1038/s41589-023-01526-9

Highlights from the 24th workshop on vitamin D in Austin, September 2022

Meyer MB, Bernal-Mizrachi C, Bickle DD, Biyani M, Campbell MJ, Chaudhari SN, et. al.
J Steroid Biochem Mol Biol 2023 (10), 228:106247

Host-microbiome orchestration of the sulfated metabolome

D’Agostino GD, Chaudhari SN, Devlin AS.
Nature Chemical Biology 2024, doi: 10.1038/s41589-023-01526-9

Highlights from the 24th workshop on vitamin D in Austin, September 2022

Meyer MB, Bernal-Mizrachi C, Bickle DD, Biyani M, Campbell MJ, Chaudhari SN, et. al.
J Steroid Biochem Mol Biol 2023 (10), 228:106247

Host-microbiome orchestration of the sulfated metabolome

D’Agostino GD, Chaudhari SN, Devlin AS.
Nature Chemical Biology 2024, doi: 10.1038/s41589-023-01526-9

Highlights from the 24th workshop on vitamin D in Austin, September 2022

Meyer MB, Bernal-Mizrachi C, Bickle DD, Biyani M, Campbell MJ, Chaudhari SN, et. al.
J Steroid Biochem Mol Biol 2023 (10), 228:106247

Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury

Li DK, Chaudhari SN, Lee Y, Sojoodi M, Adhikari AA, Zukerberg L, Shroff S, Barrett SC, Tanabe K, Chung RT, Devlin AS.
Science Advances 2022, 8 (34).
Research spotlight: Harvard Medical School Instagram

Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury

Chains of evidence from correlations to causal molecules in microbiome-linked diseases

Chaudhari SN, McCurry MD, Devlin AS.
Nature Chemical Biology 2021, 17 (10), 1046–1056.
Research spotlight: Nature Chemical Biology cover

Chains of evidence from correlations to causal molecules in microbiome-linked diseases

Chaudhari SN, McCurry MD, Devlin AS.
Nature Chemical Biology 2021, 17 (10), 1046–1056.
Research spotlight: Nature Chemical Biology cover

A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases

Adhikari AA, Ramachandran D, Chaudhari SN, Powell CE, McCurry MD, Banks AS, Devlin AS.
ACS Chemical Biology 2021, 16 (8), 1401–1412.

A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases

Adhikari AA, Ramachandran D, Chaudhari SN, Powell CE, McCurry MD, Banks AS, Devlin AS.
ACS Chemical Biology 2021, 16 (8), 1401–1412.

Intestinal co-culture system to study TGR5 agonism and gut restriction

Chaudhari SN, Devlin AS.
Bio-protocol 2021, 11 (6), e3948.

A microbial metabolite remodels the gut-liver axis following bariatric surgery

Chaudhari SN, Luo JN, Harris DA, Aliakbarian H, Yao L, Paik D, Subramaniam R, Adhikari AA, Vernon AH, Kilic A, Weiss ST, Huh JR, Sheu EG, Devlin AS.
Cell Host & Microbe 2021, 29 (3), 408–424.e7.
Research Spotlight: Cell Host & Microbe preview

Intestinal co-culture system to study TGR5 agonism and gut restriction

Chaudhari SN, Devlin AS.
Bio-protocol 2021, 11 (6), e3948.

A microbial metabolite remodels the gut-liver axis following bariatric surgery

Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects

Chaudhari SN, Harris DA, Aliakbarian H, Luo JN, Henke MT, Subramaniam R, Vernon AH, Tavakkoli A, Sheu EG, Devlin AS.
Nature Chemical Biology 2021, 17 (1), 20–29.
Research spotlight: c&enb drug discovery, Nature Chemical Biology News & Views , Harvard Medical School News and Research, Translational Chemical Biology conference press highlight

Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects

Development of a covalent inhibitor of gut bacterial bile salt hydrolases

Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD, Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin AS.
Nature Chemical Biology 2020, 16 (3), 318–326.
Research spotlight: Nature Chemical Biology cover

The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity

Chaudhari SN & Kipreos ET.
Bioessays 2018, e1800005

Development of a covalent inhibitor of gut bacterial bile salt hydrolases

The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity

Chaudhari SN & Kipreos ET.
Bioessays 2018, e1800005

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

Chaudhari SN & Kipreos ET.
Nature Communications 2017, 8, 182

Primary Culture System for Germ Cells from Caenorhabditis elegans Tumorous Germline Mutants

Vagasi AS, Bi G, Rahman MM, Chaudhari SN, Kipreos ET.
Bio Protoc 2017, 7 (15), e2424

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

Chaudhari SN & Kipreos ET.
Nature Communications 2017, 8, 182

Primary Culture System for Germ Cells from Caenorhabditis elegans Tumorous Germline Mutants

Vagasi AS, Bi G, Rahman MM, Chaudhari SN, Kipreos ET.
Bio Protoc 2017, 7 (15), e2424

Dafachronic acid inhibits C. elegans germ cell proliferation in a DAF-12-dependent manner

Mukherjee M, Chaudhari SN, Balachandran RS, Vagasi AS & Kipreos ET.
Developmental Biology 2017, 432, 215-221,

Dafachronic acid inhibits C. elegans germ cell proliferation in a DAF-12-dependent manner

Mukherjee M, Chaudhari SN, Balachandran RS, Vagasi AS & Kipreos ET.
Developmental Biology 2017, 432, 215-221,

Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation

Chaudhari SN, Mukherjee M, Vagasi AS, Bi G, Rahman MM, Nguyen CQ, Paul L, Selhub J, Kipreos ET. Developmental Cell 2016, 38, 33-46
Research spotlight: Developmental Cell preview

Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation

Chaudhari SN, Mukherjee M, Vagasi AS, Bi G, Rahman MM, Nguyen CQ, Paul L, Selhub J, Kipreos ET. Developmental Cell 2016, 38, 33-46
Research spotlight: Developmental Cell preview

Enhanced resolution through thick tissue with structured illumination and adaptive optics

Thomas B, Wolstenholme A, Chaudhari SN, Kipreos ET, Kner P.
J. Biomed. Opt. 2015, 0001;20(2):026006.

Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

Danner R, Chaudhari SN, Rosenberger J, Richie TL, Brumeanu T, Casares S.
PLoS ONE 2011, 6: e19826

Enhanced resolution through thick tissue with structured illumination and adaptive optics

Thomas B, Wolstenholme A, Chaudhari SN, Kipreos ET, Kner P.
J. Biomed. Opt. 2015, 0001;20(2):026006.

Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

Danner R, Chaudhari SN, Rosenberger J, Richie TL, Brumeanu T, Casares S.
PLoS ONE 2011, 6: e19826

Patents

Methods for inducing bile acid sulfotransferase sult2a for treating metabolic disorders WO-2021226447-A1 link
Synthetic derivatives of cholic acid-7-sulfate and uses thereof WO/2020/117945 link
Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes WO2020041673A1 link